Synthesis of some new quinazolin-4 (3H)-ones and their biological activities

Author & Affiliation:
Pankaj Kumar
Department of Chemistry, D.N. (P.G.) College, Meerut - 250 002 (INDIA) Amoli Organics, Pvt. Ltd., Turbhe, Navi Mumbai - (INDIA)
Payal Singh
Department of Pharmacology, L.I.R.M., Medical College, Meerut (INDIA)
Jai Singh
Department of Pharmacology, L.I.R.M., Medical College, Meerut (INDIA)
S.M. Sharma
Department of Pharmacology, L.I.R.M., Medical College, Meerut (INDIA)
A.K. Mishra
Department of Pharmacology, L.I.R.M., Medical College, Meerut (INDIA)
Ashok Kumar
Department of Pharmacology, L.I.R.M., Medical College, Meerut (INDIA)
Keyword:
Quinazolin-4(3H)-ones, anti-inflammatory, analgesic, ulcerogenic cyclooxygenase activities
Issue Date:
April 2008
Abstract:

5-Iodoanthranilic acid, 5-bromo anthranic acid, acetanthranils or benzoxazinones, 2-methyl-3-(p-methylphenyl)-6-iodo quinazolin-4(3H)-ones, 2-bromomethyl-3-(p-methylphenyl)-6- iodoquinazolin-4(3H)-ones, 2-hydrazino methyl-3-(p-methylphenyl)-6-iodoquinazolin-4(3H)-ones,1-[2'-methylene-3-(p-methylphenyl)-6-iodoquinazolin-4(3H)-onyl-4-(ochlorophenyl)-2-(2''-phenylindol-3''-yl)-2-pyrazolines have been prepared. Their structures have been established by elemental analysis. IR spectra, NMR spectra and mass spectra. All the compounds have been tested for their anti-inflammatory activity, analgesic activity, ulcerogenic activity and cyclooxygenase activity.
 

Pages:
5-16
ISSN:
2319-8052 (Online) - 2231-3478 (Print)
Source:
DOI:
jusps-B
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Copy the following to cite this article:

P. Kumar; P. Singh; J. Singh; S. Sharma; A. Mishra; A. Kumar, "Synthesis of some new quinazolin-4 (3H)-ones and their biological activities", Journal of Ultra Scientist of Physical Sciences, Volume 20, Issue 1, Page Number 5-16, 2018

Copy the following to cite this URL:

P. Kumar; P. Singh; J. Singh; S. Sharma; A. Mishra; A. Kumar, "Synthesis of some new quinazolin-4 (3H)-ones and their biological activities", Journal of Ultra Scientist of Physical Sciences, Volume 20, Issue 1, Page Number 5-16, 2018

Available from: http://www.ultraphysicalsciences.org/paper/1353/

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