Evaporate minerals are often occurred by evaporation processes in a closed sedimentary basin. These minerals can show distinctive assemblages of minerals in a depositional environment. One of the important objectives of multi-spectral and developed multi-spectral sensors is the detection of optical characteristics of the Earth's surface using spectral bands. The evaporate minerals in the Evaz-Heerm area have been investigated in the field and have been successfully detected by applying FCC (False Color Composite), MNF (Minimum Noise Fraction Transform) and MEM (Mathematical evaluation method) techniques on Landsat TM4 imageries. Halite, gypsum, anhydrite and dolomite minerals can be distinguished. This study shows clearly the capability of Landsat TM4 data in the detection of evaporate minerals in the Evaz-Heerm area, and the MEM method can be comfortable technique for the Landsat TM4 imagery data. The pervasive assemblage of evaporate minerals indicate that the Evaz-Heerm area belongs to a closed depositional basin.